"F."
F. V. Hebard
Research Farms
American Chestnut
     Foundation
Meadowview, VA
Fred@acf.org
www.acffarms.org

Co-Authors
Bob Paris
William White
Shaun Yarnes
Mila Wilmoth

Outline
Physiology and Histology
Fungus Pathogenicity
Resistance Tests

Physiology and Histology
Initial Lesion Formation

Physiology and Histology
Mycelial fan is means of breakout from initial lesion.

Physiology and Histology
Mycelial fans advance by physical pressure.

Physiology and Histology
In American chestnut, mycelial fans form more rapidly, in greater numbers, and grow more quickly than in Chinese chestnut, which is resistant to blight.

Physiology and Histology
Cells die in advance of hyphae - living cells indicated here by diaphorase activity stained with Nitro-Blue Tetrazolium

Physiology and Histology
Enzyme activity in initial lesion and lignifying zone - esterase, phenolase, beta-glucosidase

Physiology and Histology
Canker size dynamics

Physiology and Histology
Physiology and Histology
Ethylene levels near cankers

Physiology and Histology
Ethylene can be elicited by a low-molecular-weight carboxylic acid from culture filtrates on chestnut bark broth, which is not oxalate. Oxalate does not elicit ethylene.

Physiology and Histology
Ethylene as measure of colonization; it is elicited more relative to basal levels in American chestnut than Chinese

Fungus
pathogenicity
Fungus Pathogenicity
Demonstration of statistically significant differences in canker length on American chestnut for virulent isolates of Cryphonectria parasitica

Fungus Pathogenicity
Unlike on susceptible American chestnut, strain SG2-3 gives qualitatively smaller cankers than Ep155 on trees with intermediate levels of resistance, such as this one.

Fungus Pathogenicity
Resistance Tests
Resistance Tests
Mean canker size in Aug & Sept after June Inoculation for various chestnut crosses in a single test

Resistance Tests
Resistance Tests
Resistance Tests - mortality
Resistance Tests - mortality
Resistance Tests -
Qualitative Rating Scheme
Small, Medium and Large Cankers

Resistance Tests -
Qualitative Rating Scheme
Resistance Tests
In 2004 or 2005, some trees that scored well in 1993 started displaying fairly severe cankers.
Was resistance breaking down (pathogen mutating)?
Was the test in error?
Or was this normal canker development for Chinese chestnut?
So we went back and rated all the living trees from the 1993 test (and also isolated the blight fungus from cankers).

Resistance Tests
Connecting results from 1993 to tree size and canker severity in 2006.  Difficult.

Is this basic test of inoculating trees in late spring and rating them that summer to early winter and the following spring capturing all the components of resistance?
What about sclerified phelloderm?

Sclerified Phelloderm
Initial Observation

Sclerified Phelloderm
Expectations based on hypothesis

Sclerified Phelloderm
Periderm, the outer skin of bark

Sclerified Phelloderm
Wound periderm

Sclerified Phelloderm
Evidence of Sclerification of Phelloderm

Sclerified Phelloderm
Observing chunks of bark using epifluorescence

Sclerified Phelloderm
Images of chunks of bark with sclerified periderm

Expectation #1
Chinese but not American trees will show sclerification

Expectation #2
The presence of sclerified phelloderm will correlate with resistance measurements in backcross trees.

Expectation #3
Selection for resistant trees will inadvertently be a selection for sclerification.

Sclerified Phelloderm
Patterns of inheritance in families where sclerification occurs of
none+incomplete vs. complete

Sclerified Phelloderm
Future Directions

Crew at Meadowview, 2009